Letrozole works by blocking the action of the enzyme aromatase, which prevents the body from converting androgens into estrogens. Bone pain, joint pain or muscle ache. If you dont get your period after taking letrozole, take a pregnancy test. Taking letrozole after tamoxifen can help lower the risk of your cancer coming back. Burstein, H. J. (2014). (Off-label use is when a drug thats approved to treat one condition is used to treat another condition.) 39,784 people reported to have side effects when taking Letrozole. Letrozole is sometimes used off-label to treat infertility in females. Around 6% experienced weight loss. Your doctor will explain how you should take letrozole oral tablets. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. Aching or pain in the joints and muscles is often mild and temporary, although for some people its more severe and longer lasting. Common side effects of Oxytrol include: local pruritus. By signing up, I agree to GoodRx's Terms and Privacy Policy, and to receive marketing messages from GoodRx. If you have diarrhoea, its important to drink enough fluids. osteoporosis, osteopenia (low bone mineral density); You should not breastfeed while you are using letrozole and for at least 3 weeks after your last dose. Different pharmacies offer different prices for the same medication. Night sweats may be annoying, but theyre not dangerous. This includes cancer cells. Other drugs that have the same active ingredients (e.g. Here are a few tips that might help guide your discussion: Remember, your doctor and other healthcare professionals are available to help you. Nausea and vomiting Letrozole may also make you feel sick (nausea) or be sick (vomiting). Some people find mindfulness practices, such as yoga and meditation, are helpful also. The phase IV clinical study analyzes which people take Letrozole and have Urinary tract infection. A healthy diet and exercise can help lower your cholesterol. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. What should I know about letrozole vs. anastrozole? If youre concerned about this you may find it helpful to speak to your specialist. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Letrozole. (2009). In addition, Oxytrol (oxybutynin) is only moderately effective for relieving overactive bladder symptoms--like all drugs in its class--and it can cause dry mouth and constipation. If its hard for you to read the label on your prescription, tell your doctor or pharmacist. You may have questions about letrozole oral tablets and your treatment plan. Cerner Multum, Inc. "UK Summary of Product Characteristics." Letrozole is a targeted aromatase inhibitor which has primarily been used in post-menopausal women with breast cancer. Theyll also explain how much to take and how often. Before using anti-inflammatory pain relief, ask your doctor about the correct dose, how long you should use it for and any possible side effects, especially if you have a stomach ulcer or asthma. It is often used in breast cancer. Avoid driving or hazardous activity until you know how letrozole will affect you. Check whether Urinary tract infection is associated with a drug or a condition, Urinary tract infection and drugs with ingredients of letrozole, Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection), Urinary tract infection in Moderna COVID Vaccine, Urinary tract infection in Pfizer BioNTech Covid Vaccine, Urinary tract infection in Johnson and Johnson Covid Vaccine, Plan B and Lithium Carbonate drug interaction, Lung Cancer Metastatic and Metastases To Meninges, Folic Acid and Fluvastatin Sodium drug interaction, Nicotinamide and Aripiprazole drug interaction, Gaviscon and Blood Alkaline Phosphatase Increased, Vitamins and Mibelas 24 Fe drug interaction. Mild pain relief such as paracetamol may help with headaches. The use of the eHealthMe site and its content is at your own risk. Call your doctor for medical advice about side effects. Some of these women will conceive with letrozole; There can be unpleasant side effects with Clomid that cause women to stop taking it This can be a reason to use Femara instead of Clomid; Femara and Pregnancy - Success Rates Using Femara and Letrozole. With this interaction, tamoxifen can reduce how well letrozole works. People with breast cancer have a higher risk of blood clots such as a deep vein thrombosis (DVT). These symptoms can include: An itchy or burning sensation in your vagina and vulva. To help prevent pregnancy while youre taking letrozole, you should use birth control. Sometimes it can go away on its own, but it can take months to get better. Medically reviewed by Drugs.com on May 4, 2022. High levels in liver disease: Letrozole is broken down by liver enzymes. Find out more about hair loss and thinning. Read on to learn more about letrozole oral tablets uses, dosage, side effects, and more. We comply with the HONcode standard for trustworthy health information. Taking letrozole with or after food can help reduce nausea. If you struggle to maintain a healthy weight, ask your GP or specialist about being referred to a dietitian. Its not mentioned how much weight people gained or lost during these studies. This is why chemotherapy can cause hair loss and many other side effects. This drug may cause weak bones. Dosage form: oral tablet (2.5 mg) If your cancer is hormone receptor-negative, then letrozole will not be of any benefit. They may be able to offer ways of improving your symptoms. I was checked for an infection but that came back clear. If you have a certain type of breast cancer, your doctor may prescribe letrozole for you. Many people find that symptoms improve over time. Letrozole lowers the amount of estrogen in the body. Try to avoid alcohol, caffeine, or smoking, because they can worsen these symptoms. Some of these can happen when common side effects go unchecked: Bone fractures: As discussed above, bone loss that happens with the long-term use of letrozole can lead to bone fractures. Certain pharmacies provide medication labels that: Your doctor or pharmacist may be able to recommend a pharmacy that offers these options if your current pharmacy doesnt. Lets review. With approval from my oncologist and urogyn, I use a small amount of . (2021). Melatonin and Breast Cancer: Is it Safe and Can it Help? StatPearls. Similar to treating headaches, OTC medications can help ease joint pain. Letrozole (Femara) can cause fatigue, dizziness, and sleepiness. Note: This document contains side effect information about oxybutynin. Additionally, sometimes you may receive letrozole by itself after youve had treatment with radiation or surgery. Please seek medical advice before starting, changing or terminating any medical treatment. To understand diagnoses, you should understand breast cancer staging and what each means for overall outlook. European Journal of Cancer. So while they might improve hot flashes, they could interfere with how letrozole works. Estrogen is important for bone health. Breckenridge Pharmaceutical, Inc. (2020). Dont take more letrozole oral tablets than your doctor prescribes. This will usually be from a group of drugs called bisphosphonates. In certain types of infertility like that caused by polycystic ovary syndrome (PCOS) an egg may not be released at the correct time, or at all. Follow up with your healthcare provider to get regular screening for bone loss and cholesterol changes while using letrozole. If you have liver disease, your healthcare provider may recommend a lower dose. Speak with your healthcare provider if youre concerned about any weight changes you experience. Common side effects Speak to your GP or treatment team if you have any of these symptoms. This causes pain, tingling and numbness in your arm, hand or fingers. visible water retention temporary redness of face and neck weight gain headache nausea generalized weakness drug-induced hot flashes INFREQUENT side effects If experienced, these tend to have a. Trademarks, brands, logos, and copyrights are the property of their respective owners. After menopause, aromatase is the main source of estrogen production. Oncologist wasn't bothered about it and did suggest me taking cranberry juice but not one I have tried. Its a very common side effect of breast cancer treatment and may affect you physically and emotionally. Letrozole can harm an unborn baby. They can tell you if its safe for you to take the medication with letrozole. This may raise the chance of broken bones. GoodRx provides no warranty for any information. But sometimes, metformin is given together with clomiphene to help treat infertility in females with PCOS. They can assess you and offer advice on how to manage your energy levels. Heres a list of common questions related to taking letrozole. It can also help to increase egg production in women who ovulate normally but have unexplained infertility. If you have a certain type of breast cancer, your doctor may prescribe letrozole oral tablets for you. Others find exercise improves their mood. Side effects tend to go away once letrozole is stopped. You will need frequent medical tests, and your bone mineral density may also need to be checked. You may also want to check out the online communities at Bezzy. Your doctor or pharmacist can tell you more about these interactions and any others that may occur with use of letrozole oral tablets. Now, youll enjoy a streamlined experience created specifically for healthcare providers. Its used to treat certain types of breast cancer in adult females* whove gone through menopause. Can Breast Cancer Be Detected in a Complete Blood Count (CBC)? Exercise that gently stretches your joints or strengthens your muscles to better support your joints, such as yoga or pilates, may help improve your symptoms. Letrozole is a pill you take by mouth (with or without food), so you can take it with a meal if you prefer. These symptoms usually improve or become easier to manage over time. If you miss a dose, do not double your dose the next day. All rights reserved. Let your doctor know about your missed period and your test results. Instead, its a type of hormone therapy. If these side effects become too bothersome, talk to your healthcare provider about other options. Letrozole lowers estrogen levels in postmenopausal women, which may slow the growth of certain types of breast tumors that need estrogen to grow in the body. These include side effects such as flushing, hot flashes, or headaches. Stopping letrozole isnt known to cause withdrawal symptoms or any other side effects. Letrozole versus clomiphene for infertility in the polycystic ovary syndrome. If you have a certain type of breast cancer, your doctor may prescribe letrozole for you. Femara ( letrozole) is a non-steroidal aromatase inhibitor (lowers estrogen production) used to treat breast cancer in postmenopausal women. You should not use letrozole if you are pregnant. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy. Letrozole oral tablets are a generic drug, which means theyre an exact copy of the active drug in a brand-name medication. early breast cancer (breast cancer that hasnt spread beyond your breast or, locally advanced breast cancer (breast cancer thats spread to areas near your breast or in the lymph nodes in your armpit), feeling weak or having increased tiredness, swelling, usually in your arms, feet, hands, or legs, cardiovascular (heart or blood vessel) problems, such as. If your doctor thinks letrozole has stopped working for you, talk with them about whether stopping the drug could be beneficial for you. There are CDs, podcasts and phone apps that can guide you through these techniques. This does not change the effectiveness of the treatment. Since inflammation may be associated with joint pain, adding turmeric (mixed with freshly ground black pepper and olive oil for bioavailability) to foods or taking supplements may help relieve symptoms. How many cycles of letrozole are needed to get pregnant? Most of the time this Candida transfer is harmless, so yeast infections are not highly contagious. There's no way to completely predict or prevent breast cancer. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. (PCOS can affect ovulation, and its one of the more common causes of infertility in females. Using letrozole during pregnancy can be harmful to the baby. Clomid is no longer available, but its generic version, clomiphene, is still available. Australian prescription products guide online. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. About 30% of people reported hot flashes when using letrozole for breast cancer. Contains side effect of breast cancer, your doctor or pharmacist means for overall outlook food can help reduce.. Your arm, hand or fingers by itself after youve had treatment with or... In women who ovulate normally but have unexplained infertility and urogyn, agree! Cycles of letrozole are needed to get better the action of the active drug in a Complete blood Count CBC! Same medication tests, and sleepiness can help lower the risk of blood clots such as a substitute the., they could interfere with how letrozole will not be of any.! 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