Consequently, there is not yet enough evidence to evaluate the efficacy of pregabalin in the treatment of neuropathic pain within patients with cancer. However, there are some promising data that warrant further research to assess the efficacy and safety of pregabalin for the treatment of neuropathic pain within patients with cancer. The randomized controlled trial reported lower mean VAS pain scores for pregabalin patients following 3 weeks of treatment compared with amitriptyline, gabapentin, and placebo . Data from clinical studies show that Lyrica (pregabalin) shares this analgesic effectiveness. In patients with cancer, neuropathic pain can result from the primary malignancy (e.g., compression and/or infiltration of nerve tissue by the tumor) , radiotherapy treatment , chemotherapy , administration of the oncology treatment , or cancer-related surgery . Mean pain intensity scores were measured on a self-reported 11-point numerical rating scale (0 = no pain to 10 = worst imaginable pain) . Effective pharmacological treatments are scarce, but … In an open-label observational study, Toelle et al. Information about its use in people with head and neck pain is lacking. Its use in epilepsy is as an add-on therapy for partial seizures. There is potential for phenobarbital, clonazepam, valproic acid, topiramate, pregabalin and tiagabine to have antihyperalgesic and antinociceptive activities based on result in animal models of neuropathic pain, but the efficacy of these drugs in the treatment of human neuropathic pain has not yet been fully determined in clinical trials. Discuss the Lyrica consumer medicine information (CMI) leaflet with the patient and inform about common side effects such as dizziness and drowsiness. Drug therapy is best used as part of a multifaceted, multidisciplinary, active self-management approach to the physical, psychological, social and vocational impacts of neuropathic pain.5 Assess the nature of the pain experience and inform people of realistic outcomes with treatment.6,7 The primary goal in most cases is to make the pain tolerable — not usually to eliminate the pain.6 Aim for medium-term drug therapy with a drug holiday after 6 months. Introduction: Pregabalin is an anticonvulsant with one known mechanism of action which is used most specifically in the management of neuropathic pain. Search for other works by this author on: Integrated Health, Pfizer, Capelle a/d IJssel, The Netherlands, Primary Care Europe, Pfizer, Tadworth, UK, International Association for the Study of Pain, Differential diagnosis: Nociceptive and neuropathic pain, Assessment of cancer-related neuropathy and neuropathic pain, Prevalence of neuropathic pain in radiotherapy oncology units, Burden of chemotherapy-induced neuropathy–a cross-sectional study, Types and epidemiology of cancer-related neuropathic pain: The intersection of cancer pain and neuropathic pain, Prevalence and aetiology of neuropathic pain in cancer patients: A systematic review, Neuropathic pain in cancer patients—Prevalence and management in a tertiary care anesthesia-run referral clinic based in urban India, Neuropathic pain features in patients with bone metastases referred for palliative radiotherapy, Pain, neuropathic symptoms, and physical and mental well-being in persons with cancer, Prevalence of undertreatment in cancer pain. A literature search was conducted on February 22, 2012 in PubMed using the following search terms: neuropath* AND pain AND cancer OR oncology OR tumor OR tumour AND pregabalin (Figure 0001). A recent publication reporting outcome criteria for assessing neuropathic pain in patients with cancer noted that, in general, there are very few published randomized controlled trials that assess the effect of specific treatments . Arezzo JC Rosenstock J Lamoreaux L Pauer L. Lesser H Sharma U LaMoreaux L Poole RM. The mechanism of action for pain alleviation by pregabalin: Pregabalin blocks the VGCC and hence decrease glutamate and sensory neuropeptides (substance P and CGRP) release at synapse by decreasing Ca2+ influx. To gamma-aminobutyric acid ( GABA ) - an inhibitory neurotransmitter in week 4, mean VAS with pregabalin include:12 health! Observational analyses, and indirect comparisons suggest it is non-inferior for efficacy and safety for... 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